Plasmonic Nanogap Probes for Surface-Enhanced Raman Scattering-Based Bioimaging and Analysis

Surface-enhanced Raman scattering (SERS) utilizes nanostructures to amplify Raman signals, making it a powerful tool for molecular detection and analysis. When plasmonic nanostructures are in close proximity, electromagnetic fields become highly localized in specific regions called hot spots. These regions, typically found in the gaps inside and between metal nanoparticles, significantly enhanced Raman signal intensity, enabling the detailed detection of biomolecules within cells. This review explores recent developments in the design and application of plasmonic nanogap structures for SERS, with a particular emphasis on their innovative applications in biological imaging. It highlights how these advances provide high-resolution, highly sensitive detection capabilities, potentially transforming bioimaging technologies.