Impact of body composition on pathological response to neoadjuvant immunotherapy in dMMR/MSI-H colorectal cancer

Higher visceral adipose tissue volume is associated with improved pathological complete response in dMMR/MSI-H colorectal cancer patients treated with PD-1 inhibitors. However, this favorable effect of visceral adiposity may be diminished or reversed in elderly patients (≥ 65 y), highlighting the potential influence of aging on the metabolic-immune interplay in immunotherapy response.