转录因子
亮氨酸拉链
bZIP域
拉链
DNA
抄写(语言学)
遗传学
生物
计算生物学
DNA结合蛋白
结构母题
序列(生物学)
基因
生物化学
语言学
哲学
算法
计算机科学
作者
Špela Tomaž,Kristina Gruden,Anna Coll
标识
DOI:10.3389/fpls.2022.935819
摘要
TGA transcription factors are essential regulators of various cellular processes, their activity connected to different hormonal pathways, interacting proteins and regulatory elements. Belonging to the basic region leucine zipper (bZIP) family, TGAs operate by binding to their target DNA sequence as dimers through a conserved bZIP domain. Despite sharing the core DNA-binding sequence, the TGA paralogues exert somewhat different DNA-binding preferences. Sequence variability of their N- and C-terminal protein parts indicates their importance in defining TGA functional specificity through interactions with diverse proteins, affecting their DNA-binding properties. In this review, we provide a short and concise summary on plant TGA transcription factors from a structural point of view, including the relation of their structural characteristics to their functional roles in transcription regulation.
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