自愈水凝胶
黄原胶
聚丙烯酰胺
生物相容性
材料科学
伤口愈合
极限抗拉强度
肿胀 的
粘附
生物医学工程
复合材料
化学工程
高分子化学
流变学
外科
医学
冶金
工程类
作者
Song Tang,Zhoujie Gong,Zefan Wang,Xia Gao,Xiaonan Zhang
标识
DOI:10.1016/j.ijbiomac.2022.07.181
摘要
Developing advanced dressings that integrate multiple functions is one of the major challenges in current clinical wound treatment. In this study, Xanthan gum (XG) and polyacrylamide (PAAm) materials were used to prepare hydrogel dressings by one-pot method. With the combination of the PAAm network and the XG network, the PAAm-XG hydrogels showed the tensile strength of 0.36 MPa and the stretchability as large as 2078 %. The prepared PAAm-XG hydrogels had excellent water uptake efficiency with the swelling ratio of 1200 %. Besides, the developed dressings possessed outstanding biocompatibility, universal adhesion and self-healing ability. More importantly, the PAAm-XG hydrogels can be successfully loaded with Cefixime and human recombinant epidermal growth factor, and these loaded hydrogels released these bioactive molecules in sustained ways. As a result, both E. coli and S. aureus bacteria were inactivated after contacting with the Cefixime-loaded hydrogels for 24 h. Furthermore, in vivo data demonstrated that the PAAm-XG hydrogel dressings significantly accelerated the wound healing in a mouse model. All of these indicate that the multifunctional PAAm-XG hydrogels are promising candidates for wound treatment.
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