孟德尔随机化
医学
内科学
冠状动脉疾病
优势比
慢性疼痛
心脏病学
心房颤动
冲程(发动机)
体质指数
风险因素
萧条(经济学)
物理疗法
机械工程
生物化学
化学
宏观经济学
遗传变异
基因型
工程类
经济
基因
作者
Jiahao Zhu,Nini Wang,Houpu Liu,Han Jiang,Bingyue Cai,Dingwan Chen,Yingjun Li
出处
期刊:Pain
[Ovid Technologies (Wolters Kluwer)]
日期:2022-07-21
卷期号:164 (3): e135-e143
被引量:5
标识
DOI:10.1097/j.pain.0000000000002732
摘要
The potential consequences of the number of chronic pain sites (referred to multisite chronic pain) on the risk of cardiovascular diseases (CVDs) remain unclear. We attempted to investigate the causality of multisite chronic pain with CVDs and its possible causal mediators. Using summary genome-wide association statistics, two-sample Mendelian randomization (MR) analyses were performed to assess whether multisite chronic pain has a causal effect on the 3 CVDs including coronary artery disease, atrial fibrillation, and stroke. We then conducted MR mediation analyses to establish whether body mass index (BMI), smoking, and depression causally mediate any association. Genetic liability to multisite chronic pain was associated with increased risk of coronary artery disease (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.19-1.95 per one increase in the number of pain locations) but not with atrial fibrillation or stroke. We also found positive causal effects of multisite chronic pain on BMI, smoking, and depression and causal effects of BMI, smoking, and depression on coronary artery disease. In multivariable MR analyses, the excess risk of coronary artery disease was attenuated after adjusting for BMI (OR 1.43, 95% CI 1.05-1.93), smoking (OR 1.49, 95% CI 1.11-2.00), depression (OR 1.44, 95% CI 1.03-2.01), and 3 risk factors combined (OR 1.34, 95% CI 0.88-2.05). Our findings demonstrated that multisite chronic pain led to higher risk of coronary artery disease, which is partly mediated through BMI, smoking, and depression.
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