生物
硫氧化物9
纤维化
计算生物学
细胞生物学
遗传学
转录因子
内科学
基因
医学
作者
Darrian Bugg,Jennifer Davis
标识
DOI:10.1016/j.stem.2024.04.009
摘要
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.
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