Dual epigallocatechin gallate and camptothecin loaded electrospun meshes for synergy combination chemotherapy of colon cancer

Abstract Combination chemotherapy based on electrospun fibrous was a promising strategy to applied synergy effects in treatment for colon cancer. Herein, Lactic acid/glycolic acid (PLGA) meshes with different ratios of epigallocatechin gallate (EGCG) and camptothecin (CPT) were manufactured. Results of X‐ray diffraction (XRD) revealed both EGCG and CPT were amorphous in meshes. Drug release experiments indicated that EGCG and CPT could be released sustainably while the dual drug‐loaded meshes had a higher release rate than single drug‐loaded meshes. Importantly, these meshes displayed obvious cytotoxicity against CT‐26 cells in anti‐colon cancer experiments, and the combination index values of all dual drug‐loaded meshes were around 0.5, suggesting strong synergy effect of EGCG and CPT. These results showed dual EGCG and CPT loaded meshes had application potential in effective synergistic therapy for colon cancer.