下调和上调
毛乳头
毛囊
异硫氰酸盐
化学
血管内皮生长因子
信使核糖核酸
细胞生物学
内分泌学
生物
血管内皮生长因子受体
癌症研究
生物化学
基因
作者
Tomoe Yamada‐Kato,Isao Okunishi,Yousuke Fukamatsu,Hidenori Tsuboi,Yusuke Yoshida
出处
期刊:Food Science and Technology Research
[Japanese Society for Food Science and Technology]
日期:2018-01-01
卷期号:24 (3): 567-572
被引量:3
摘要
Wasabi is a member of the Brassicaceae family and produces various isothiocyanates (ITCs). Because 6-methylsulfinylhexyl ITC (6-MSITC) is stable among wasabi ITCs, it has potential as a functional compound. Hair loss can have psychological and social effects on an individual because of its impact on appearance. In this study, we investigated the stimulatory effects of 6-MSITC by culturing on human follicle dermal papilla cells (DPCs). Results showed that 6-MSITC significantly promoted DPC proliferation and upregulated vascular endothelial growth factor (VEGF) mRNA levels compared to control. Furthermore, 6-MSITC significantly upregulated adenosine A2b receptor (ADORA2b) mRNA levels. Previous studies have reported that VEGF was induced through ADORA1 and ADORA2 pathways. We suggest that 6-MSITC stimulates hair growth on DPCs related to the upregulation of ADORA2b mRNA level. Thus, 6-MSITC may be used as a functional compound.
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