电容感应                        
                
                                
                        
                            生物医学工程                        
                
                                
                        
                            电容                        
                
                                
                        
                            材料科学                        
                
                                
                        
                            心电图                        
                
                                
                        
                            电极                        
                
                                
                        
                            心律                        
                
                                
                        
                            心率                        
                
                                
                        
                            计算机科学                        
                
                                
                        
                            医学                        
                
                                
                        
                            心脏病学                        
                
                                
                        
                            内科学                        
                
                                
                        
                            化学                        
                
                                
                        
                            物理化学                        
                
                                
                        
                            血压                        
                
                                
                        
                            操作系统                        
                
                        
                    
            作者
            
                Ting-Wei Wang,Shien‐Fong Lin            
         
                    
        
    
            
            标识
            
                                    DOI:10.1088/1361-6501/ab8cfc
                                    
                                
                                 
         
        
                
            摘要
            
            Abstract Rat electrocardiography (ECG) is frequently used in biomedical research as a model for exploring heart function in a wide variety of experimental conditions. Subcutaneous ECG is a common approach to record rat heart rhythm using implanted needle electrodes to sense the rat ECG signals with the animal under deep anesthesia. However, such an invasive measurement could cause inconvenience due to cumbersome animal preparation, and the anesthetics are likely to interfere with the autonomic regulation of cardiac rhythm. Most studies used the galvanic contact between animal limb and electrode sensing surface to record cardiac signals from small animals. However, the non-contact approach of capacitive ECG sensing for small laboratory animals has not been extensively investigated. This study aims to develop a non-contact ECG system to promote the ECG measurement of laboratory animals for biomedical research. The method utilizes the capacitive coupling technique to detect cardiac signals in awake rats (R-wave amplitude of only 0.2 mV) through a non-conductive layer. The proposed system generates non-contact ECG signals with distinguishable R-peaks at a limb-electrode capacitance above 8.5 pF and maximum through-thickness of the non-conductive layer of 0.4 mm for heart rate assessment. In conclusion, this study provides non-contact ECG monitoring based on capacitive electrodes to improve the throughput of ECG measurement procedures for biomedical research and establish a lower bound of coupling capacitance for non-contact application to heart rate. The new method is ideally suited for the rapid evaluation of autonomic regulation of heart rhythm in awake laboratory small animals.
         
            
 
                 
                
                    
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