Synthesis of Simplified Halogenated Chondramide Derivatives with Strong Cytostatic Properties

Abstract Removing the methyl groups and the stereogenic centers from the ω‐hydroxy acid of the chondramides results in a significant drop in the cytotoxicity of these interesting depsipeptides. This effect can be almost compensated for by introduction of a second chlorine atom on the β‐tyrosine moiety of the natural products. These simplified chondramides are much easier accessible than natural chondramides.