[P2–450]: DISCRIMINATIVE ABILITY OF EVERYDAY COGNITION (ECOG) SCALE FOR PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE (SCD IN MEMORY CLINICS

Several questionnaires have been established to evaluate subjective cognitive decline (SCD), but few of which focus on informant estimation. The 12-item Everyday cognition (ECog) scale is proved to be sensitive for mild cognitive impairment(MCI). We aimed to study the application of Ecog in discriminating patients with SCD. Data were collected from the memory clinic of Huashan Hospital, Shanghai FuDan University, China. Participants included 325patients, 100with SCD(50.0% female, age=69.34±7.203, education=9.55±3.735), 112with MCI(50.0%female, age=69.23±7.472, education=9.44±3.656), 113 with AD(48.7%female, age=69.49±8.479, education=9.51±3.543). Cognitive performance was estimated by a standardized neuropsychological test battery included Chinese version of Mini-Mental state examination (CMMSE), auditory learning test (AVLT-H), Category Fluency (Animals), Boston Naming Test(BNT), Trail Making Test (Part A and B), Rey-Osterreich complex figure test(CFT), Stroop color and word test(CWT). Diagnostic group differences were examined using one-way analysis of variance. Receiver operating characteristic curves (ROC) determined sensitivities, specificities, and the area under the ROC curve (AUC) were created to examine the discriminative properties of the scales between diagnostic groups (i.e., SCD versus MCI, SCD versus AD and SCD versus MCI). The mean ECog score was 1.65±0.505 for SCD, 2.06±0.604 for MCI, and 2.81±0.638 for AD. There were significant differences in average ECog score among three diagnostic groups (P<0.01). The capability of the ECog-12 on discriminating between individuals with SCD and MCI is poor (AUC=0.706, sensitivity=74.11%, specificity=56%, cutoff score=1.67). The discrimination between individuals with AD and MCI group was the highest (AUC=0.923, sensitivity=89.38%, specificity=86%, cutoff score=2.00). The discrimination between SCD and AD was intermediate (AUC=0.801, sensitivity=94.69%, specificity=51.79%, cutoff score=1.92). The performance of 12-item ECog for discriminating SCD is not as good as for MCI in memory clinics.