The present study is designed to investigate the antibacterial activity of flower extracts of Quisqualis indica Linn. againstgram-positive as well as gram -negative bacterial strains. For this, a gar well diffusion assay method was appliedto determinetheantibacterial activity of the extracts .The flower extract s with different solvents (methanol, ethanol and aqueous) showed remarkable antibacterial activity against the testedbacterial strains. Among the tested bacterial strains, Micrococcus luteuswas highly susceptible to the flowerextract as compared with theBacillus subtilis and E.coli.The results also showed that the methanolic extract of Quisqualis indica was the most effective as the widest inhibitory zone was observed ascompared to the e thanolic as well as aqueous extract.It is inferred from the present investigation that demonstration of antibacterial activity of the studied flower extractsagainst both gram-positive and gram-negative bacteria may be indicative of the presence of broad-spectrum antibacterialcompounds, suggests that there is a scientific basis for its utilization as antibacterial agents in designing and developing new drugs.