Diamond anvil cell(DAC)is a kind of static ultra-high pressure device with advantages of high hardness and good transmittance which is superior than other high-pressure device.Raman spectrum is an important means for characterizing the structure and the changes of matter.The combination of DAC high pressure experimental technique and laser Raman spectroscopy can provide an effective way for high-pressure structural change.In this paper the β-Ga2O3 and SrSO4 are studied using diamond anvil cell under high-temperature and high-pressure conditions.