Objective:To study the mechanism and related factors of post-stroke depression(PSD).Methods:Investigate the occurrence and clinical features of depression with a Hamilton depression scale(HAMD)between 90 patients with stroke(stroke group) and 68 patients with diabetes(control group).Results: The incidence of post-stroke depression(57.78%) was significantly higher than The control group(8.82﹪)(P0.01).Activities of daily living rating(ALD)scales showed that patients with depression is 79±4.5 and non-depressed patients is 85±6.2(P0.01).The European stroke scale(ESS)standard display that depression group is 62.05±4.3 and non-depressed group is 69.20±9.8(P0.01).The incidence of depression of Associated with speech difficulties(88.24%)is significantly higher than the unassociated with speech difficulties(50.5%).(P0.05).Conclusions: The incidence of post-stroke depression is related to Dependence on daily activities and Degree of neurological deficits.The incidence of depression of Associated with speech difficulties was significantly higher.