OBJECTIVE: To utilize traditional Chinese medicine (TCM) resource in mountain area, and to improve teaching effect of Pharmacognosy. METHODS: Based on the characteristics of TCM resource in mountain area, teaching reform of Pharmacognosy was carried out. RESULTS: Three combination was carried out continuously in the teaching of Pharmaognosy, so that Three improved significantly, i.e. the first one was enhancing the ability of practice by utilizing traditional Chinese medicine resource; the second one was to combine the theory of sustainable development to developing exploiting ability; the third one was combining the medicinal essence to improve initiating ability. CONCLUSION: The emphasis on three combination and three are effective means for elevating teaching reform of Pharmacognosy.