Dissolution monitor of acyclovir tablets by fiber-optic medicine dissolution process real time test system

Objective To establish an analytical method for the dissolution of acyclovir tablets and evaluate their intrinsic quality. Methods The dissolution process of acyclovir tablets was determined with FODT-601 fiber-optic medicine dissolution process real time test system. Results The real-time dissolution profiles of acyclovir tablets from 9 manufacturers were determined.There was significant difference in the dissolution profiles.One of the dissolution profiles showed comparatively large intra-batch variance. Conclusion This process analysis can reflect the real dissolution process and can provide useful information for improving the preparation technology and monitoring its stability.