Objective:To study the effect of Chaizhijingzhuo Pills on experimental prostatitis pathological model. Methods:The rat prostatitis pathological model with fibroid hyperplasia was established by injecting xiaozhiling into the prostatic dorsal lobe of rat. Results:Chaizhijingzhuo Pills could significantly inhibit the prostatitis cytoinfiltration and the hyperplasia of interstitial fibroblastic cells induced by Xiaozhiling. It also increased the secretion of adenocyte. Conclusion:Chaizhijingzhuo Pills has inhibition on the experimental prostatis of rat.