The development of treatment of hepatorenal syndrome

Hepatorenal syndrome(HRS) is a common complication of serious liver disease with a very high mortality.Its pathogenesis is not very clear.The main clinical symptom is the functional renal failure,which is crucial for the correct diagnosis of this kind of disease.The treatment is mainly aimed at the changes in circulation and the insufficiency of renal blood capacity.We can choose the vasoactive drugs which have strong action on the systemic vaso-contraction but with a minimal effect on renal blood flow.In addition,in order to correct the states of hyperdynamic-circulation,it should be used in combination with the plasma expansion.And blood purification system can be used to improve the renal function.Transjugular intrahepatic portosystemic shunt(TIPS) should be used to reduce portal hypertension,and the best treatment for HRS is to implement liver transplantation.Strenuous efforts should be made to prevent the occurrence of HRS.