Chromatographic Characterization of Fosfomycin Modified Zirconia Support

Lewis acid sites are supposed to present on the surface of zirconia and are responsible for the very strong adsorption of Lewis bases. Such sites can be masked or modified by compounds which contain Lewis base groups. Fosfomycin can interact strongly with these sites on zirconia because of its phosphonic structure. In this paper, zirconia was modified by fosfomycin with both dynamic and static methods. The chromatographic behavior of some compounds was investigated on these stationary phases. The retention of the acid compounds decreased significantly on the fosfomycin modified zirconia, compared to that on the native zirconia. Dynamically modified zirconia exhibited more hydrophobic than the statically modified zirconia.