Secondary Structure Changes of Melittin Induced by Phospholipid Monolayer

Melittin is the major protein component of the venom of European honey bee Apismellifera.It has 26 amino acids with molecular weight of 2840.The peptide has a netcharge of +6 and is very soluble in water(>250 mg/ml).Melittin reaches membranethrough the aqueous phase.Previous experiments show that melittin-membraneinteractions need no specific receptor.Study of melittin-membrane interactions helps to un-derstand the molecular mechanisms of melittin-induced hemolysis and set a model for