DISTINCT MICROSATELLITE ALTERATIONS IN UPPER URINARY TRACT TUMORS AND SUBSEQUENT BLADDER TUMORS

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Feb 2001DISTINCT MICROSATELLITE ALTERATIONS IN UPPER URINARY TRACT TUMORS AND SUBSEQUENT BLADDER TUMORS TAKESHI TAKAHASHI, YOSHIYUKI KAKEHI, KENJI MITSUMORI, TOSHIYA AKAO, TOSHIRO TERACHI, TETSURO KATO, OSAMU OGAWA, and TOMONORI HABUCHI TAKESHI TAKAHASHITAKESHI TAKAHASHI , YOSHIYUKI KAKEHIYOSHIYUKI KAKEHI , KENJI MITSUMORIKENJI MITSUMORI , TOSHIYA AKAOTOSHIYA AKAO , TOSHIRO TERACHITOSHIRO TERACHI , TETSURO KATOTETSURO KATO , OSAMU OGAWAOSAMU OGAWA , and TOMONORI HABUCHITOMONORI HABUCHI View All Author Informationhttps://doi.org/10.1097/00005392-200102000-00092AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Although synchronous and/or metachronous tumor development is common in urothelial cancer, genetic and biological differences in upper urinary tract and bladder tumors are unclear. We compared the genetic alteration pattern in multifocal disease in patients with upper urinary tract and subsequent bladder tumors, and those with recurrent bladder tumor. Materials and Methods: Using 21 microsatellite markers on the 8 chromosomal arms 2q, 4p, 4q, 8p, 9p, 9q, 11p and 17p we analyzed 34 tumors from 15 patients with upper urinary tract and subsequent bladder disease, and 70 tumors from 22 with recurrent bladder disease. Results: Judging from the patterns of genetic alterations multifocal tumors were considered to have derived from an identical progenitor cell in 7 of 13 evaluable patients (54%) with upper urinary tract and subsequent bladder tumors, and 16 of 19 (84%) who were evaluable with recurrent bladder tumor. These data confirm the view that seeding or intraepithelial spread is a major mechanism for the multifocal development of urothelial cancer in general. However, a discordant microsatellite alteration pattern in multifocal tumors was observed in 6 of 7 patients (86%) with upper urinary tract and subsequent bladder lesions but in 2 of 16 (13%) with recurrent bladder cancer (p <0.005). Conclusions: Our results imply that upper urinary tract neoplasms may be genetically more unstable than bladder neoplasms. The implantation of tumor cells from upper urinary tract to bladder may involve additional and diverse genetic alterations. Furthermore, a considerable number of multifocal upper urinary tract and subsequent bladder lesions may arise independently via field cancerization mechanism. Our study indicates that the factors contributing to multifocal development are different in the 2 groups. References 1 : Urothelial tumors of the urinary tract. In: . New York: W. B. Saunders1997: 2327. chapt. 77. Google Scholar 2 : Clonal origin bladder cancer. New Engl J Med1992; 326: 737. Google Scholar 3 : c-erbB-2 Amplification and identical p53 mutations in concomitant transitional carcinomas of renal pelvis and urinary bladder. Lancet1992; 339: 439. Google Scholar 4 : Metachronous multifocal development of urothelial cancers by intraluminal seeding. Lancet1993; 342: 1087. Google Scholar 5 : Clonal and chronological genetic analysis of multifocal cancers of the bladder and upper urinary tract. Cancer Res1998; 58: 5835. Google Scholar 6 : Modified nephro-ureterectomy. Long-term follow-up with particular reference to subsequent bladder tumours. Br J Urol1988; 61: 198. Google Scholar 7 : Tumor grade and stage as prognostic variables in upper tract urothelial tumors. Cancer1988; 62: 2016. Google Scholar 8 : Carcinoma of the ureter: a clinicopathologic study of 49 cases. J Urol1989; 142: 280. Abstract, Google Scholar 9 : Association of in vitro growth potential of urinary exfoliated cells with tumor localization and intraluminal recurrence rates of urothelial cancers. J Urol1997; 158: 1996. Link, Google Scholar 10 : Epidemiology and treatment of renal pelvic and ureteral tumors. J Urol1975; 114: 858. Link, Google Scholar 11 : Family history of cancer among cases of upper urothelial tumours in a Balkan nephropathy area. J Cancer Res Clin Onco1985; 110: 181. Google Scholar 12 : Urothelial susceptibility to tumor cell implantation: influence of cauterization. Cancer1980; 46: 1158. Google Scholar 13 The Genome Database: An International Collaboration in Support of the Human Genome Project. Available from http://www.gdb.org. Accessed July 7, 1998. Google Scholar 14 : Allelic losses of chromosomes 9, 11 and 17 in human bladder cancer. Cancer Res1990; 50: 44. Google Scholar 15 : Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder. Cancer Res1990; 50: 7081. Google Scholar 16 : Genetic alterations in bladder cancer. Lancet1993; 342: 469. Google Scholar 17 : Allelotype of human bladder cancer. Cancer Res1994; 54: 531. Google Scholar From the Departments of Urology, Kyoto University Graduate School of Medicine, Kyoto and Akita University School of Medicine, Akita, Japan© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKuroiwa K, Inokuchi J, Nishiyama H, Kojima T, Kakehi Y, Sugimoto M, Tanigawa T, Fujimoto H, Gotoh M, Masumori N, Ogawa O, Eto M, Ohyama C, Yokomizo A, Matsuyama H, Ichikawa T, Mizusawa J, Eba J and Naito S (2019) Impact of Previous, Simultaneous or Subsequent Bladder Cancer on Prognosis after Radical Nephroureterectomy for Upper Urinary Tract Urothelial CarcinomaJournal of Urology, VOL. 202, NO. 6, (1127-1135), Online publication date: 1-Dec-2019.PALOU J, RODRÍGUEZ-RUBIO F, HUGUET J, SEGARRA J, RIBAL M, ALCARAZ A and VILLAVICENCIO H (2018) MULTIVARIATE ANALYSIS OF CLINICAL PARAMETERS OF SYNCHRONOUS PRIMARY SUPERFICIAL BLADDER CANCER AND UPPER URINARY TRACT TUMORJournal of Urology, VOL. 174, NO. 3, (859-861), Online publication date: 1-Sep-2005.AMIRA N, RIVET J, SOLIMAN H, CANCEL-TASSIN G, LE DUC A, JANIN A and CUSSENOT O (2018) Microsatellite Instability in Urothelial Carcinoma of the Upper Urinary TractJournal of Urology, VOL. 170, NO. 4 Part 1, (1151-1154), Online publication date: 1-Oct-2003.DONAT S, BAYUGA S, HERR H and BERWICK M (2018) Fluid Intake and the Risk of Tumor Recurrence in Patients With Superficial Bladder CancerJournal of Urology, VOL. 170, NO. 5, (1777-1780), Online publication date: 1-Nov-2003.BÖHLE A, JURCZOK A, ARDELT P, WULF T, ULMER A, JOCHAM D and BRANDAU S (2018) INHIBITION OF BLADDER CARCINOMA CELL ADHESION BY OLIGOPEPTIDE COMBINATIONS IN VITRO AND IN VIVOJournal of Urology, VOL. 167, NO. 1, (357-363), Online publication date: 1-Jan-2002. Volume 165Issue 2February 2001Page: 672-677 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsgenetics, biochemicalurinary tracturologic neoplasmsbladderbladder neoplasmsMetricsAuthor Information TAKESHI TAKAHASHI More articles by this author YOSHIYUKI KAKEHI More articles by this author KENJI MITSUMORI More articles by this author TOSHIYA AKAO More articles by this author TOSHIRO TERACHI More articles by this author TETSURO KATO More articles by this author OSAMU OGAWA More articles by this author TOMONORI HABUCHI More articles by this author Expand All Advertisement PDF downloadLoading ...