化学
异噻唑
炔丙基
组合化学
基质(水族馆)
钯
催化作用
功能群
硼酸
转化(遗传学)
甲苯
催化循环
有机化学
聚合物
地质学
海洋学
基因
生物化学
作者
K. Sandeep,Alla Siva Reddy,K. C. Kumara Swamy
摘要
An efficient and straightforward Pd-catalysed synthesis of diversely substituted sultams utilising ynamides and boronic acids is disclosed; toluene was found to be the most suitable solvent for this transformation. This strategy has been successfully applied to generate dihydrobenzo[d]isothiazole 1,1-dioxides and dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxides. The advantages of this protocol are good functional group tolerance, broad substrate scope, high-yielding reaction and low catalyst loading to access benzofused sultams with five-/six-membered rings. The synthetic utility has been demonstrated by a gram-scale synthesis. A plausible catalytic cycle involving carbopalladation has been proposed for this transformation.
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