单宁酸
肉芽组织
明胶
壳聚糖
聚吡咯
纤维接头
再生(生物学)
材料科学
聚合
伤口愈合
生物医学工程
血管生成
涂层
化学
纳米技术
复合材料
外科
医学
聚合物
癌症研究
生物化学
有机化学
细胞生物学
生物
作者
Qian Zhang,Yansha Qiao,Jianhua Zhu,Yimeng Li,Chaojing Li,Lin Jing,Xiaoli Li,Hui Han,Fujun Wang
标识
DOI:10.1016/j.compositesb.2021.109140
摘要
Surgical sutures pervade almost all surgeries; however, their clinical therapy effects are barely satisfactory due to the lack of physiological signal responsiveness and the prone surgical site infection (SSI). Herein, the functional sutures ([email protected]) with electroactivity and antibacterial properties were fabricated by decorating the suture surfaces with chitosan-gelatin/tannic acid/polypyrrole (CS-GE/TA/PPy) composite coating. Thanks to the assistance of CS-GE/TA on the polymerization of PPy, the inherent brittleness of PPy was alleviated and ensured [email protected] excellent conductivity even under knotted state, thereby providing stable physiological electrical signal transmission among cells and regulating cell behaviors actively. Meanwhile, the synergistic effects of CS-GE/TA and PPy offered [email protected] outstanding antibacterial rates of over 99% against E. coli and S. aureus without involving any additional drugs. Furthermore, in vivo studies revealed that [email protected] could enhance wound healing dramatically, as evidenced by less inflammatory reaction, better angiogenesis, cell proliferation, re-epithelization, granulation tissue, and collagen regeneration. This study successfully demonstrates the feasibility of the electroactive and antibacterial sutures for promoting tissue regeneration and provides a new idea for exploring the next generation bioactive suture.
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