生物
自噬
复印件
细胞生物学
ATG8型
自噬体
高尔基体
复印机
内质网
液泡
内体
分泌途径
ATG12
液泡蛋白分选
袋3
内膜系统
作者
Yonglun Zeng,Liwen Jiang
出处
期刊:Autophagy
[Informa]
日期:2021-05-28
卷期号:17 (7): 1785-1787
标识
DOI:10.1080/15548627.2021.1933298
摘要
Increasing evidence supports the bona fide function of the coat protein complex II (COPII) machinery in regulating autophagosomes biogenesis during macroautophagy/autophagy induced by nutrient starvation. However, the participation of the COPII machinery in the plant autophagy pathway remains elusive. We recently identified a unique population of COPII vesicles containing AT3G62560/AtSar1d-AT1G02130/AtRabD2a that functions in modulating autuphagosome biogenesis in Arabidopsis thaliana. Proteomic analysis identified the mechanistic connection between autophagy-related (ATG) proteins and a subset of specific COPII paralogs, including AtSar1d. Mutants of AtSar1d affect autophagosome progression and display starvation-related phenotypes. AtSar1d interacts with ATG8 by a non-canonical motif. Cellular and genetic analysis demonstrated that a plant-unique RAB1/Ypt1 homolog AtRabD2a coordinates with AtSar1d to mediate the specific COPII functions in the autophagy pathway. This study identified a plant-specific nexus in regulating autophagosome biogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI