姜黄素
聚乙二醇
溶解度
生物相容性
肿胀 的
药物输送
溶剂
PEG比率
甲醇
自愈水凝胶
材料科学
化学
高分子化学
聚合
聚合物
毒品携带者
化学工程
有机化学
生物化学
复合材料
经济
工程类
财务
作者
Zahra Ayar,Mehdi Shafieian,Narges Mahmoodi,Omid Sabzevari,Zahra Hassannejad
摘要
Abstract This study was designed to develop a drug delivery system based on poly(N‐isopropylacrylamide) (pNIPAM) hydrogel and a suitable solvent to enhance solubility and local release of curcumin. pNIPAM hydrogel was synthesized by radical polymerization. The chemical, mechanical and physical properties and biocompatibility of pNIPAM hydrogel were investigated as an implantable and rechargeable drug reservoir. Curcumin was loaded within pNIPAM hydrogel during swelling by using two different solvents; methanol, an organic solvent, and low molecular weight polyethylene glycol (PEG200), a polymeric solvent. The results of drug solubility showed that using PEG200 can increase curcumin solubility more than commonly used organic solvents such as methanol. Also, the release profile of drug‐loaded hydrogels demonstrated that PEG200 has a superior effect on the cumulative amount of released curcumin (33.163 ± 0.319 μg/ml) compared to methanol (8.765 ± 0.544 μg/ml) during 1 week. Based on our results, curcumin‐loaded hydrogels did not show any cytotoxicity, and pNIPAM/PEG combination represented an antibacterial effect within 12 hours. Accordingly, it can be concluded that pNIPAM hydrogel in combination with low molecular weight PEG200 could be used as an efficient drug delivery system to preserve and provide sustained release of curcumin as a hydrophobic drug.
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