开放式参考框架
生物
打开阅读框
基因组
编码
计算生物学
背景(考古学)
人类蛋白质组计划
蛋白质组
遗传学
翻译(生物学)
蛋白质组学
基因
肽序列
信使核糖核酸
古生物学
作者
Bradley W. Wright,Zixin Yi,Jonathan S. Weissman,Jin Chen
标识
DOI:10.1016/j.tcb.2021.10.010
摘要
Omics-based technologies have revolutionized our understanding of the coding potential of the genome. In particular, these studies revealed widespread unannotated open reading frames (ORFs) throughout genomes and that these regions have the potential to encode novel functional (micro-)proteins and/or hold regulatory roles. However, despite their genomic prevalence, relatively few of these noncanonical ORFs have been functionally characterized, likely in part due to their under-recognition by the broader scientific community. The few that have been investigated in detail have demonstrated their essentiality in critical and divergent biological processes. As such, here we aim to discuss recent advances in understanding the diversity of noncanonical ORFs and their roles, as well as detail biologically important examples within the context of the mammalian genome.
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