氟氯西林
医学
多药
胆汁淤积
肝损伤
入射(几何)
黄疸
重症监护医学
内科学
药品
金黄色葡萄球菌
药理学
细菌
物理
光学
生物
遗传学
作者
Roberta Angheleanu,Johnny Swart
出处
期刊:Case Reports
[BMJ]
日期:2021-05-06
卷期号:14 (5): e241071-e241071
被引量:2
标识
DOI:10.1136/bcr-2020-241071
摘要
Flucloxacillin is a penicillin antibiotic used as first-line treatment for soft tissue infections caused by Staphylococcus aureus . It is used frequently in the elderly and is an established cause of cholestatic liver injury. Risk factors for cholestasis include prolonged duration of treatment, female sex and older age. Elderly patients are also more likely to suffer from comorbidities and polypharmacy, which increases the incidence of drug-induced liver injury and hospitalisation, which in turn can lead to irreversible deterioration in functional baseline. Our case report aims to raise awareness of flucloxacillin-induced liver injury in elderly patients and to encourage the use of alternative treatments and/or limited duration. We advocate for further research into individualised treatments and new diagnostic techniques in patients with painless jaundice based on their genotype.
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