生物能学
氧化磷酸化
线粒体
细胞生物学
生物
功能(生物学)
线粒体DNA
氧化代谢
新陈代谢
生物化学
基因
作者
Sara Cogliati,José Antonio Enrı́quez,Luca Scorrano
标识
DOI:10.1016/j.tibs.2016.01.001
摘要
Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.
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