内化
吸附
黑色素瘤
癌症
癌症研究
纳米颗粒
化学
生物物理学
纳米技术
材料科学
医学
内科学
生物
生物化学
细胞
物理化学
作者
Hongyuan Song,Quyi Xu,Yu Zhu,Shiying Zhu,Hailin Tang,Yan Wang,Hao Ren,Ping Zhao,Zhongtian Qi,Shijun Zhao
出处
期刊:Nanomedicine
日期:2015-12-01
卷期号:10 (24): 3547-3562
被引量:39
摘要
To investigate the biological fate of cuprous oxide nanoparticles (Cu2O-NPs) and to evaluate their potential in uveal melanoma therapy.The protein corona, cellular uptake mechanism and localization of Cu2O-NPs were investigated. Furthermore, the effect of Cu2O-NPs on uveal melanoma cell proliferation, migration and invasion, and possible mechanisms were studied in detail.Cu2O-NPs are able to adsorb serum proteins in cell culture medium, which are then internalized by uveal melanoma cells mainly through lipid raft-mediated endocytosis. Furthermore, Cu2O-NPs selectively inhibit cancer cell growth and impair the ability of uveal melanoma cell migration, invasion and the cytoskeleton assembly. The mechanism may be that Cu2O-NPs located in and damage mitochondria, autophagolysosomes and lysosomes, leading to elevated reactive oxygen species level and over-stimulated apoptosis and autophagy.The data provide detailed information of Cu2O-NPs for further application and indicate that Cu2O-NPs could be a potential agent for uveal melanoma therapy.
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