Novel Angiogenic Factors for Predicting Preeclampsia: sFlt-1, PlGF, and Soluble Endoglin~!2008-08-29~!2008-12-15~!2009-01-02~!

Preeclampsia is a devastating multisystem syndrome and is a major cause of maternal, fetal and neonatal morbidity and mortality.Angiogenic factors contribute to the molecular mechanisms of preeclampsia and its main phenotypes such as hypertension and proteinuria.Very recently, novel anti-angiogenic proteins including soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and one pro-angiogenic protein placental growth factor (PlGF) have been found to be significantly abnormal several weeks preceding the onset of clinical signs and symptoms.Automatic immunoassays are being developed for sFlt-1 and PlGF.This article will summarize our current knowledge of these markers and their roles on predicting preeclampsia.