化学
对映选择合成
二乙基锌
结合
催化作用
对映体
组合化学
对映体过量
锌
有机化学
药物化学
数学
数学分析
作者
Gonzalo Blay,M. Carmen Muñoz,José R. Pedro,Amparo Sanz‐Marco
标识
DOI:10.1002/adsc.201201120
摘要
Abstract A new enantioselective catalyst for the conjugate addition of terminal alkynes has been developed. Terminal alkynes react with 3‐alkoxycarbonylcoumarins in the presence of diethylzinc and bis(hydroxyamide) ligands to give chiral non‐racemic dihydrocoumarins substituted with an alkynyl group on the C‐4 position with good yields and enantiomeric excesses up to 95%.
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