高尿酸血症
黄嘌呤氧化酶
尿酸
黄嘌呤
排泄
化学
内分泌学
药理学
内科学
生物化学
生物
医学
酶
作者
Shinichi Honda,Seiji Kawamoto,Hozumi Tanaka,Hideyuki Kishida,Masayoshi Kitagawa,Yuji Nakai,Keiko Abe,Dai Hirata
标识
DOI:10.1080/09168451.2014.890028
摘要
We applied Chrysanthemum flower oil (CFO) to a hyperuricemia model by feeding rats a hyperuricemia-inducing diet (HID) and investigated its effect on serum uric acid (SUA) levels and its mode of action. CFO is the oily fraction that contains polyphenols derived from chrysanthemum flowers. Oral administration of CFO to HID-fed rats significantly decreased their SUA levels. It also inhibited xanthine oxidase activities in the liver and increased urine uric acid levels. The effects of CFO on the renal gene expressions that accompanied the induction of hyperuricemia were comprehensively confirmed by DNA microarray analysis. The analysis showed up-regulation of those genes for uric acid excretion by CFO administration. These results suggest that CFO suppresses the increase in SUA levels via two mechanisms: suppression of uric acid production by inhibition of xanthine oxidase in the liver and acceleration of its excretion by up-regulation of uric acid transporter genes in the kidney.
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