Influence of Cytokines and Growth Factors on Distinct Steroidogenic Enzymes in Vitro

A bstract : Cytokines (IL‐1, IL‐6, IL‐8, IL‐11, TNF, IFN‐γ, and TGF‐β) and growth factors (EGF, bFGF, aFGF, and KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps of steroidogenesis in various endocrine cell types. For this tabular data collection, the following enzyme steps were considered: steroidogenic acute regulatory protein (StAR), side chain cleavage enzyme (P450scc), 3 beta‐hydroxysteroid dehydrogenase, 17‐alpha‐hydroxylase/17,20‐lyase (P450c17), 17‐beta‐hydroxysteroid‐dehydrogenase, aromatase complex, 5‐alpha‐reductase, P450c21, DHEAS sulfatase, and DHEA sulfotransferase. This collection summarizes the current information on how the mentioned cytokines and growth factors influence particular enzyme steps.