骨髓炎
骨小管
骨细胞
表皮葡萄球菌
微生物学
金黄色葡萄球菌
病理
疾病
生物
葡萄球菌
医学
免疫学
细菌
成骨细胞
生物化学
遗传学
体外
作者
Louise Kruse Jensen,Julie Melsted Birch,Henrik Elvang,Klaus Kirketerp,Hans Gottlieb
出处
期刊:Apmis
[Wiley]
日期:2023-05-11
卷期号:131 (7): 325-332
被引量:2
摘要
Two chronic osteomyelitis patients, a diabetic foot osteomyelitis patient and a fracture-related infection patient, all with staphylococci-positive microbiology, were examined to confirm the clinical relevance of bacterial invasion of the submicron osteocyte lacuna-canaliculi network (OLCN) in bone tissue. Based on immunohistochemistry and light microscopy both Staphylococcus aureus and Staphylococcus epidermidis were identified within the OLCN of all four patients. The findings consolidate that bacterial OLCN invasion is a clinically relevant part of osteomyelitis disease biology, which from experimental porcine infections, seems to be time depending. The microscopy pictures of the four patients significantly add to visualize the phenomenon of bacterial OLCN invasion.
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