环己酮
化学
催化作用
酚类
亲电芳香族取代
苯酚
电泳剂
钴
Atom(片上系统)
光化学
反应性(心理学)
分子
有机化学
组合化学
替代医学
病理
计算机科学
嵌入式系统
医学
作者
Henry P. Caldora,Zhenhua Zhang,Michael J. Tilby,Oli Turner,Daniele Leonori
标识
DOI:10.1002/anie.202301656
摘要
Phenols are integral aromatic molecules widely encountered in the structure of natural products and routinely utilised for the synthesis of high-value materials. Accessing highly substituted derivatives can often be difficult, especially when their functionalization pattern does not match the intrinsic reactivity leveraged by electrophilic aromatic substitution (SE Ar) chemistry. Here, we provide an alternative and mechanistically distinct approach for phenol synthesis using saturated cyclohexanone precursors. This process operates at ambient temperature, under simple purple light irradiation, and features a dual catalytic manifold carrying four sequential H-atom transfer processes.
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