Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts

In this issue, Abe et al 1 Abe Y. Kofman E.R. Almeida M. Ouyang Z. Ponte F. Mueller J.R. Cruz-Becerra G. Sakai M. Prohaska T.A. Spann N.J. et al. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1beta- and RNA-dependent co-activator of osteoclast gene expression. Mol. Cell. 2023; 83https://doi.org/10.1016/j.molcel.2023.08.029 Abstract Full Text Full Text PDF Google Scholar report a novel mechanism by which RANKL stimulates osteoclast differentiation and bone resorption through non-coding RNAs that bind PGC-1β and convert the NCoR/HDAC3 co-repressor complex into a co-activator of AP-1- and NFκB-regulated genes. In this issue, Abe et al 1 Abe Y. Kofman E.R. Almeida M. Ouyang Z. Ponte F. Mueller J.R. Cruz-Becerra G. Sakai M. Prohaska T.A. Spann N.J. et al. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1beta- and RNA-dependent co-activator of osteoclast gene expression. Mol. Cell. 2023; 83https://doi.org/10.1016/j.molcel.2023.08.029 Abstract Full Text Full Text PDF Google Scholar report a novel mechanism by which RANKL stimulates osteoclast differentiation and bone resorption through non-coding RNAs that bind PGC-1β and convert the NCoR/HDAC3 co-repressor complex into a co-activator of AP-1- and NFκB-regulated genes.