纳米载体
化学工程
核化学
磁性纳米粒子
材料科学
动态光散射
化学
吸附
药物输送
纳米颗粒
热重分析
吸附
纳米技术
有机化学
工程类
作者
Hafez Khodayari,Amir Heydarinasab,Elham Moniri,Mahsasadat Miralinaghi
标识
DOI:10.1016/j.inoche.2022.110366
摘要
pH-sensitive magnetic nanocarrier was fabricated by the graft of hyaluronic acid/β-cyclodextrin onto Fe3O4 magnetic nanoparticles for doxorubicin delivery. The surface morphology, magnetic property, thermal stability, and chemical structure of the magnetic nanocarrier were studied using field emission scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometer, thermal gravimetric analysis, Fourier-transform infrared spectroscopy, X-ray diffraction, and Brunauer-Emmett-Teller techniques. Doxorubicin as a chemotherapy drug, in-vitro release behavior was performed at two pH levels (simulated human blood fluid (pH = 7.4) and simulated cancer fluid (pH = 5.6)) and indicated strong pH dependence. The pH-sensitive release behavior of the nanocarrier shown higher doxorubicin release at pH = 5.6 (92.43%; 48 h) than at pH = 7.4 (77.05%; 48 h). Also, the results shown that the doxorubicin release mechanism from nanocarrier was controlled by Fickian diffusion kinetic. The data of the sorption shown that the surface modification of Fe3O4 magnetic nanoparticles has a great impact on the drug sorption and increased it, and indicated this procedure is more compatible with Langmuir isotherm and pseudo-second-order kinetic models. Moreover, thermodynamic parameters indicated that the doxorubicin adsorption is endothermic and spontaneous. Also, the value of the Gibb's free energy and enthalpy indicated physiochemical sorption. The obtained data could introduce pH-sensitive nanocarrier as a high potential drug delivery system.
科研通智能强力驱动
Strongly Powered by AbleSci AI