Dual-Locked Nanophotosensitizer Harnessing Cerenkov Radiation for Deep Tumor Therapy

Zr-PHZ-BrCyE exhibited robust tumor inhibition and excellent biosafety in both subcutaneous and orthotopic H22 tumor models. This approach holds great promise for improving the therapeutic outcomes of CR-PDT in deep-seated tumors while ensuring good biosafety, paving the way for future potential clinical applications in the future.