伤口愈合
医学
斑马鱼
糖尿病足
血管生成
糖尿病
炎症
动物模型
生物信息学
外科
癌症研究
内科学
生物
内分泌学
生物化学
基因
作者
Bangchang Lin,Jiahui Ma,Yimeng Fang,Pengyu Lei,Lei Wang,Linkai Qu,Wei Wu,Libo Jin,Da Sun
出处
期刊:Bioengineering
[MDPI AG]
日期:2023-03-06
卷期号:10 (3): 330-330
被引量:1
标识
DOI:10.3390/bioengineering10030330
摘要
Diabetic foot ulcers cause great suffering and are costly for the healthcare system. Normal wound healing involves hemostasis, inflammation, proliferation, and remodeling. However, the negative factors associated with diabetes, such as bacterial biofilms, persistent inflammation, impaired angiogenesis, inhibited cell proliferation, and pathological scarring, greatly interfere with the smooth progress of the entire healing process. It is this impaired wound healing that leads to diabetic foot ulcers and even amputations. Therefore, drug screening is challenging due to the complexity of damaged healing mechanisms. The establishment of a scientific and reasonable animal experimental model contributes significantly to the in-depth research of diabetic wound pathology, prevention, diagnosis, and treatment. In addition to the low cost and transparency of the embryo (for imaging transgene applications), zebrafish have a discrete wound healing process for the separate study of each stage, resulting in their potential as the ideal model animal for diabetic wound healing in the future. In this review, we examine the reasons behind the delayed healing of diabetic wounds, systematically review various studies using zebrafish as a diabetic wound model by different induction methods, as well as summarize the challenges and improvement strategies which provide references for establishing a more reasonable diabetic wound zebrafish model.
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