静电纺丝
伤口愈合
葡萄糖氧化酶
体内
生物材料
化学
纤维肉瘤
肉芽组织
生物医学工程
材料科学
生物化学
外科
酶
医学
病理
有机化学
聚合物
生物技术
生物
作者
Chao Wang,Guangchao Lv,Shiyun Feng,Chang Liu,Zhiyao Song,Hui Zhao,Li Yang,Kaizhong Wang
标识
DOI:10.1016/j.ijbiomac.2023.125876
摘要
The tumor recurrence and infected wound tissue defect are the major clinical challenges after the surgical treatment of primary chest wall cancer. Herein, to address the above issues, blending electrospinning was applied to incorporate glucose oxidase (GOx) loaded Zn/Cu-based bimetallic zeolitic imidazolate frameworks (GOx/BMOFs) into polyurethane (PU) fibers, which were designed for effective cancer therapy with improved wound healing. The release of Cu2+ and GOx could accomplish the conversion from Cu2+ to Cu+ through the glutathione (GSH) depletion and provide additional H2O2 from glucose by GOx catalysis, respectively, which further underwent the Fenton-like reaction to produce toxic hydroxyl radical (OH). The tumor cells (human fibrosarcoma cells) could be effectively killed in vitro and in vivo through the synergistic chemodynamic therapy and starvation therapy. Moreover, the electrospun fiber platform could support the adhesion and proliferation of wound tissue cells, and also show the antibacterial ability owing to the functional agents in the fibers, thereby accelerating the infected wound repair in vivo. This work may offer a reliable and effective fiber biomaterial for localized chest wall tumor therapy and simultaneous tissue regeneration.
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