Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids

Hesperetin was identified to be capable of inhibiting Aβ fibrillogenesis, disassembling mature fibrils, reducing the cytotoxicity and protecting C. elegans , and has good application prospects as a neuroprotective therapeutic agent for AD.