生物
外围设备
利基
炎症
伤口愈合
免疫系统
细胞生物学
成纤维细胞
单核细胞
免疫学
四氯化碳
皮肤修复
趋化性
分泌物
组织修复
成纤维细胞生长因子
功能(生物学)
小胶质细胞
细胞迁移
神经科学
细胞
细胞生长
再生(生物学)
趋化因子
DNA修复
肿瘤坏死因子α
核糖核酸
电池类型
癌症研究
细胞分化
神经胶质
作者
Salome Stierli,Adrián Salas-Bastos,Sofia Micheli,Isabel Ballwein,A. Kelemen,Julia Lehmann,Benjamin Loos,Whitney Jordaan,Sebastian A. Stifter,Myriam Gwerder,Ravidu Nakandalage,Janine Stadler,Melanie Greter,Lukas Sommer
出处
期刊:Cell Stem Cell
[Elsevier BV]
日期:2026-01-08
卷期号:33 (2): 272-288.e10
被引量:5
标识
DOI:10.1016/j.stem.2025.12.015
摘要
Skin repair is a complex, dynamic process involving multiple cell types. Using multiplex imaging, spatial transcriptomics, and single-cell RNA sequencing, we show that peripheral nerves—containing repair glia—form a pro-reparative niche closely interacting with macrophages and proliferating fibroblasts in acute skin wounds. Repair glia function as critical early-stage regulators of wound healing by initiating the inflammatory response through secretion of monocyte chemoattractant proteins, such as CCL2, which recruit monocyte-derived macrophages. Accordingly, depletion of repair glia as well as glia-specific deletion of CCL2 reduces the number of macrophages, leading to impaired fibroblast proliferation and diminished fibroblast-to-myofibroblast transition. These findings identify repair glia as early regulators of the immune response, orchestrating the spatiotemporal progression of wound healing. • In acute skin wounds, a pro-reparative niche forms around nerves containing repair glia • Repair glia regulate macrophage recruitment via monocyte chemoattractant proteins • Macrophages influence fibroblast proliferation and transition into myofibroblasts • Glia depletion affects the key stages of wound repair Repair glia in peripheral nerves are part of a regenerative niche in acute skin wounds. This glial niche promotes skin wound healing by regulating innate immune cell recruitment, in particular monocytes and monocyte-derived macrophages, both critical for a successful repair process.
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