线粒体DNA
原肠化
生物
细胞生物学
细胞
外胚层
否定选择
线粒体
遗传学
胚胎
胚胎发生
基因
基因组
作者
Ana Lima,Gabriele Lubatti,Joerg P. Burgstaller,Di Hu,Alistair Green,Aida Di Gregorio,Tamzin Zawadzki,Bárbara Pernaute,Elmir Mahammadov,S. Montero,Marian Dore,Juan Miguel Sánchez,Sarah Bowling,Margarida Sancho,Mohammad Karimi,David Carling,Nick Jones,Shankar Srinivas,Antonio Scialdone,Tristan A. Rodríguez
标识
DOI:10.1101/2020.01.15.900613
摘要
Abstract Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a wide range of settings from development to the adult. However, the nature of the cells normally eliminated by cell competition and what triggers their elimination remains poorly understood. In mouse, prior to gastrulation 35% of epiblast cells are eliminated. Here we have performed single cell transcriptional profiling of these cells and find that they show the hallmarks of cell competition and have mitochondrial defects. We demonstrate that mitochondrial defects are common to a range of different loser cell types and that manipulating mitochondrial function is sufficient to trigger competition. Importantly, we show that in the embryo cell competition eliminates cells with mitochondrial DNA mutations and that even non-pathological changes in mitochondrial DNA sequence can induce cell competition. Our results therefore suggest that cell competition is a purifying selection that optimises mitochondrial performance prior to gastrulation.
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