人类使用
病毒学
减毒疫苗
生物技术
医学
生物
生物化学
毒力
基因
作者
C L Wang,M Li,Xinjun Lyu
出处
期刊:PubMed
日期:2020-09-06
卷期号:54 (9): 1017-1025
被引量:2
标识
DOI:10.3760/cma.j.cn112150-20200520-00756
摘要
Human vaccine is the most effective tool to prevent infectious diseases. At present, there are dozens of vaccines that can prevent dozens of infectious diseases. Vaccines for human use include vaccines that do not contain living micro-organisms (inactivated vaccines, toxoid vaccines, component vaccines), and vaccines that contain living micro-organisms (live attenuated vaccines and vector vaccines). The research and development of human vaccine includes clinical trial, process development and test method research, and the production process of human vaccine is very important for the preparation of high-quality and reliable vaccine. In this paper, the development of human vaccines, the production process and the characteristics of various human vaccines are reviewed.人用疫苗是人类预防传染性疾病最有效的工具。目前已经有数十种人用疫苗可以预防数十种传染病。人用疫苗包括不含活微生物体的疫苗(灭活疫苗、类毒素疫苗、组分疫苗)、含活微生物体的疫苗(减毒活疫苗和载体疫苗)。人用疫苗的研发包括临床研究、工艺开发和检定方法研究,其中人用疫苗生产工艺对于制备优质、可靠的疫苗至关重要。本文就人用疫苗发展概况、人用疫苗生产工艺及各类人用疫苗的特点进行综述。.
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