产热
旁分泌信号
脂肪细胞
白色脂肪组织
褐色脂肪组织
调节器
生物
内科学
细胞生物学
脂肪组织
受体
基因
内分泌学
生物化学
医学
作者
Wenfei Sun,Hua Dong,Miroslav Baláž,Michal Slyper,Eugene Drokhlyansky,Georgia Colleluori,Antonio Giordano,Zuzana Kovaničová,Patrik Štefanička,Lucia Balážová,Lianggong Ding,Anna Sofie Husted,Gottfried Rudofsky,Jozef Ukropec,Saverio Cinti,Thue W. Schwartz,Aviv Regev,Christian Wolfrum
出处
期刊:Nature
[Springer Nature]
日期:2020-10-28
卷期号:587 (7832): 98-102
被引量:215
标识
DOI:10.1038/s41586-020-2856-x
摘要
Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite)1. It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications2,3. In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals4. Here we use single-nucleus RNA-sequencing (snRNA-seq) analysis in mice and humans to characterize adipocyte heterogeneity. We identify a rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures, and we show that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity. Human adipose tissue contains higher numbers of cells of this subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway could be used to restore thermogenic activity.
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