核梭杆菌
牙龈卟啉单胞菌
生物
牙密螺旋体
癌变
癌症
免疫系统
口腔微生物群
免疫学
厌氧菌
细菌
炎症
微生物学
癌症研究
生物信息学
微生物群
遗传学
作者
Wei‐long Zhang,Shasha Wang,Haofan Wang,Ya‐Jie Tang,Yaling Tang,Xin‐hua Liang
标识
DOI:10.1016/j.yexcr.2019.111634
摘要
Great attention has been attached to explore the association between oral bacteria and oral cancer. Recently, four common inhabitants of oral cavity, Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola and Streptococcus anginosus, have been identified as potential etiologic bacterial agents for oral carcinogenesis. They might promote the oncogenesis and progression of oral cancer by induction of chronic inflammation, enhancement of migration and invasiveness, inhibition of cell apoptosis, augment of cell proliferation, suppression of immune system and production of carcinogenic substances. Thus, this review will focus on the possible mechanisms of these oral bacteria contributing to occurrence and development of oral cancer, and the potential clinical implications of utilizing oral bacteria on the diagnosis, prevention and treatment of oral cancer will be discussed.
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