吡唑
磺酰
废止
化学
催化作用
试剂
组合化学
过渡金属
有机化学
烷基
作者
Lihong Tian,Jie‐Ping Wan,Shou‐Ri Sheng
出处
期刊:Chemcatchem
[Wiley]
日期:2020-03-31
卷期号:12 (9): 2533-2537
被引量:32
标识
DOI:10.1002/cctc.202000244
摘要
Abstract A practical protocol for the synthesis of 4‐sulfonyl pyrazoles via the reactions of readily available N,N ‐dimethyl enaminones and sulfonyl hydrazines has been developed via the catalysis of molecular iodine in the presence of TBHP and NaHCO 3 at room temperature. The pyrazole products have been constructed via the tandem C(sp 2 )−H sulfonylation and a pyrazole annulation without employing any transition metal catalyst or reagent, thus providing a practical new method for the synthesis of the novel pyrazoles bearing a sulfonyl side chain in the heterocycle.
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