氧化应激
活性氧
光动力疗法
细胞凋亡
量子点
癌细胞
石墨氮化碳
膜
化学
生物物理学
可见光谱
单线态氧
DNA损伤
材料科学
光化学
纳米技术
癌症
氧气
光催化
光电子学
医学
生物化学
生物
DNA
催化作用
有机化学
内科学
作者
Pranjali Yadav,. Mimansa,Kamalakannan Kailasam,Asifkhan Shanavas
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2022-02-22
卷期号:5 (3): 1169-1178
被引量:9
标识
DOI:10.1021/acsabm.1c01219
摘要
Graphitic carbon nitride (also known as g-CN or g-C3N4) has the intrinsic ability to generate electron-hole pairs under visible light illumination, resulting in the generation of reactive oxygen species (ROS). We report g-CN quantum dots (g-CNQDs) as a standalone photodynamic transducer for imparting significant oxidative stress in glioma cells, manifested by the loss of mitochondrial membrane potential. With an optimized treatment time, visible light source, and exposure window, the photodynamic treatment with g-CNQDs could achieve ∼90% cancer cell death via apoptosis. The g-CNQDs, otherwise biocompatible with normal cells up to 5 mg/mL, showed ∼20% necrotic cancer cell death in the absence of light due to membrane damage induced by a charge shielding effect at the acidic pH prevailing in the tumor environment. Acute toxicity analysis in C57BL/6 mice with intravenously injected g-CNQDs at a 20 mg/kg dose showed no signs of inflammatory response or organ damage.
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