超分子化学
纳米技术
肽
超分子组装
材料科学
共价键
化学
分子
生物化学
有机化学
作者
Shukun Li,Ronge Xing,Jan C. M. van Hest,Xuehai Yan
标识
DOI:10.1080/17425247.2022.2093855
摘要
Peptide-based supramolecular self-assembly has been demonstrated to be a flexible approach for the fabrication of programmable de novo nanodrugs by employing synergistic or reciprocal intermolecular non-covalent interactions. This class of nanomaterials holds significant promise for clinical translation, especially as cancer theranostics.In this review, we describe the concept of cancer theranostic drug assembly by employing non-covalent interactions. That is, molecular drugs are formulated into nanoscale and even microscale architectures by peptide-modulated self-assembly. A series of peptide-based supramolecular assembly drugs are discussed, with an emphasis on the relation between structural feature and theranostic performance.Molecular design, manipulation of non-covalent interactions, and elucidation of structure-function relationships not only facilitate the implementation of supramolecular self-assembly principles in drug development, but also provide a new means for advancing anticancer nanostructured drugs toward clinical application.
科研通智能强力驱动
Strongly Powered by AbleSci AI