Effects of Several Macrolide Antibiotics on Blood Pressure of Dogs

Among research reports on antibiotics, clinical reports on the treatment of infection occupy an overwhelming majority. In basic animal experiments, studies of antibiotics on antibacterial activity, concentration of antibiotics in the blood and distribution in the organs have received almost all of the attention, while studies on the pharmacological actions have apparently beeniieglected. One of the main reasons for this has been that the toxicity of antibiotics is far milder than that of most other synthetic drugs, and also because there is seldom any cardiovascular action at the usual therapeutic dosages.